A motorcylist is in a life-threatening condition after an accident on the A82 south of Drumnadrochit.
The Inverness to Fort William road remains closed about three miles from the village following the accident which happened about 11.15am.
The collision involved a motorcycle and a Citroen Picasso.
The male motorcyclist has been airlifted to Raigmore Hospital in Inverness by coastguard helicopter.
A police spokeswoman confirmed that his injuries are believed to life-threatening.
She added: “The road will remain closed until further notice to allow an investigation to take place.
“Drivers are advised to avoid the area and use suitable alternative routes – your patience is appreciated.”
A fire service spokesman said that a crew from Drumnadorchit, two from Inverness and a specialist heavy rescue unit had been sent to the scene.
The A82 road remains closed and drivers face a 120-mile diversion. For those travelling northbound to Inverness, drivers must turn and proceed south to Spean Bridge, head onto the A86, and then onto the A9 and follow the signs to the Highland capital.
For those heading South, head to the A82 / A9 junction in Inverness, turn right onto the A9, then right onto the A86 at Kingussie and follow to the road to Spean Bridge.