The A9 northbound was brought to a standstill following a crash near Etteridge.
The incident, involving one vehicle, occurred on the A9 Inverness to Perth trunk road on the northbound lane shortly after 6pm.
Police, firefighters and paramedics were tasked to the scene.
The northbound lane was closed to all traffic for several hours between Newtonmore and Dalwhinnie.
Motorists were being advised to use an alternative route and expect longer than normal journey times.
The road reopened at around 9pm.
The severity of any injuries is unknown at this time.
Police Scotland has been approached for comment.
Highland firefighters called to A9 crash
The Scottish Fire and Rescue Service was first notified about the crash at around 6.17pm.
Three appliances from Kingussie, Newtonmore and Pitlochry were dispatched to the scene.
Crews have since left the scene with the last appliance departing at around 7.15pm.
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A9 northbound reopens following one-vehicle crash near Etteridge
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